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These proactive systems minimize misfolding and maintain proteome efficiency during normal physiology, but they are energetically demanding and become insufficient when cells encounter substantial proteotoxic stress

Using our previous example: We have a concentration of 10mg per 1mL

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Among different types of CTD-ILD, smoking is most strongly associated with RA-ILD (2426), but studies have also shown that patients with SSc who smoke heavily have increased prevalence of emphysema and decreased survival (2729)