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BMJ (2006) 333:575

In conclusion, Nrf2 is the major down-regulator of most of the positive couplings that cause hyperinflammation and the inhibition of Nrf2 by viral proteins may be an important factor that amplifies the excessive oxidative stress and inflammatory couplings that cause the severe course of the disease or sustain the chronic state

Aging Cell 22(10):e13961

Recent evidence has shown that astrocytes are arranged in non-overlapping domains forming a syncytial network that may contact approximately 160.000 synapses, thus integrating neural activity with the vascular network [4,28]

Plays a role in energy production, DNA repair, circadian rhythm, metabolism, muscle function, tissue repair and mental clarity