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In type 2 diabetes, the reduced expression of HO-1 will increase the production of ROS, leading to oxidative stress and inflammatory reaction, further aggravating cell damage (Table 2)

Among these are the 5-adenosine monophosphate-activated protein kinase (AMPK), mitogen-activated protein kinase (MAPK), and the Janus kinase signal transducer and activator of transcription JAK-STAT) pathways, which aid in the control of cellular proliferation, mitosis, apoptosis and most aspects of the immune response [24,25,26,27,28,29,30,31,32]

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Screening and evaluation process Screening of the application During the screening stage, HSA verifies that the application type is accurate and the dossier is complete