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While these modest reductions in AKI are statistically significant, six separate meta-analyses dedicated to answering this question failed to report significant findings [33,37,38,47,48,66], and three other meta-analyses of general NAC use in cardiac surgery did not note a significant reduction in AKI when NAC was administered [40,45,49]

Although more expensive and time-consuming, animal models and human studies are more suitable for evaluation [19]

However, the precise mechanism of the zinc wave in cells remains poorly understood

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A landmark study in advanced melanoma patients demonstrated that FMT from immunotherapy-responsive donors enhanced the efficacy of PD-1 blockade therapy, with patients exhibiting increased tumour response rates and improved overall survival [138]