Abbreviations BAK: Benzalkonium chloride CCK-8: Cell Counting Kit-8 CHCl3: Chloroform CLSM: Confocal Laser Scanning Microscope CSR: Cell Survival Rate DED: Dry Eye Disease DPPC: 1,2-Dipalmitoyl-Snglycero-3-Phosphocholine DSPE-mPEG2000: 1,2-stearoyl-sn-glycerol-3-Phosphoethanolamine-N-[methoxy (polyethylene glycol)-2000 DCFH-DA: 2,7-Dichlorodihydrofluorescein Diacetate DiI: 1,1-dioctadecyl-3,3,3,3-tetramethylindocarbocyanine perchlorate DAPI: 4,6-Diamidino-2-Phenylindole DLS: Dynamic Light Scattering DL: Drug-loading EE: Encapsulation efficiency FH: Fumarate hydratase GCs: Glucocorticoids GLU: Glutamate GSH: Glutathione GPX4: Glutathione peroxidase Hyd: Hydride HCEC: Human Corneal Epithelial Cell HOS: Hyperosmolar stress H&E: Hematoxylin and Eosin INS: Insulin IGFBP-3: Insulin-like Growth Factor Binding Protein-3 INSR: Insulin Receptors IGF-1R: Insulin-like growth factor 1 receptor IGF-1: Insulin-like growth factor 1 IOP: Intraocular pressure MPTP: Mitochondrial Permeability Transition Pore MRM: Multiple Reaction Monitoring MS: Mass Spectrometry M: Mean NPs: Nanoparticles NaCL: Sodium Chloride OS: Oxidative Stress OCT: Optical coherence tomography OPLS-DA: Orthogonal projections to latent structures- discriminant analysis PEI: Polyethyleneimine PVDF: Polyvinylidene Fluoride QoL: Quality of Life ROS: Reactive Oxygen Species SDS-PAGE: Sulphate-Polyacrylamide Gel Electrophoresis SD: Standard Deviation TCA: Tricarboxylic Acid tBUT: tear Break Up Time TUNEL: Terminal Deoxynucleotidyl Transferase-mediated Nick End Labeling UHPLC: Ultra-High Performance Liquid Chromatography References Clayton JAD, Eye
Abnormal copper accumulation may alter the stability of the mitochondrial membrane, disrupt the redox balance within the mitochondria, and result in decreased intracellular energy production (Ruiz et al., 2021)
Unlike lyophilized powders stored in peptide vials , tablets require fewer handling steps
10.1016/j.bbrc.2016.03.052 114 XieY.ZhouX.LiJ.YaoX
doi: 10.1002/biof.1690 131 Bonmati-CarrionMARolMA
