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In a separate investigation, the inclusion of vitamin C was found to not only hinder the rise of reactive oxygen species count and decrease the likelihood of DNA damage and apoptosis, but also successfully prevent carboplatin from reducing the mouse oocytes' sperm binding ability and potential for fertilisation by interfering with their meiotic mechanism ( 8 Summary and outlook This paper discusses the chemical types and structures of platinum-based antitumour drugs, their mechanisms of action, routes of administration, and potential reproductive, genotoxic, and embryotoxic effects

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Our proteomics findings and subsequent validation also demonstrated an enhanced expression of the ITGAV, ITGA1 and ITGA2 in OVCAR5 CBPR versus parental OVCAR5 cell lines

Some common features of apoptosis include (a) translocation of phosphatidylserine to outer side of the plasma membrane, (b) annexin and calreticulin exposure on the cell surface, and (c) morphological changes, including condensation of the cell cytoplasm, nuclear DNA fragmentation, dissociation of cell organelles, and disruption of the cell plasma membrane