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Cartilage and bone damage in rheumatoid arthritis

Collectively, these changes contribute to oxidative DNA damage, lipid peroxidation, and follicular apoptosis (Trujillo et al

MG-induced DNA damage plays a central role in initiating apoptosis.MG induces DNA strand breaks through the formation of adducts (e.g., MGdG) and cross-linking structures with DNA, activating the intracellular DNA damage response, and triggering apoptosis by cell cycle arrest when the damage exceeds the cellular ability to repair it (104)

The Lancet Respiratory Medicine (2020)

The results suggested that the upregulation of miR-153-3p alleviated the reduction in cell viability caused by 6-OHDA and reduced the secretion of lactate dehydrogenase (LDH)