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At the mechanistic level, dysregulation of SCFAs contributes to the pathogenesis of PCOS through multiple pathways: first, decreased SCFAs (including butyrate) reduce the expression of intestinal tight junction proteins, increasing gut permeability and allowing LPS translocation into circulation, which triggers chronic low-grade inflammation

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De Waele JJ, Vogelaers D, Blot S, et al

This rapid response is due to the direct injection of Vitamin B12 into the bloodstream, which allows for quick uptake by the body

OBrien, H