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Following initiation of treatment, the bone marrow begins producing normal-sized red cells relatively quickly a reticulocyte response is typically seen within one to two weeks

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How this is achieved in fungi capable of gliotoxin, BmGT and EGT biosynthesis (Sheridan et al., 2016), all of which are highly dependent on SAM utilization, and concomitant SAH generation ( Gliotoxin Biosynthesis De novo gliotoxin biosynthesis occurs as follows: Phenylalanine and serine are condensed by the non-ribosomal peptide synthetase GliP ( (1) (Figure 3)