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After 60 days of rotenone exposure, a marked loss of TH-positive neurons and fibres were observed (Fig

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For example, brain derived neurotrophic factor (BDNF) and TNF protect neurons against excitotoxicity through activation of the transcription factor NF-kB, which induces the expression of antioxidant enzymes such as Mn-SOD and the anti-apoptotic proteins, Bcl-2 and inhibitor of apoptosis proteins IAPs [123,124]

Baseline levels of GHK-Cu in the human body peak at roughly 200 ng/mL during late adolescence (around age 20), but suffer a precipitous and permanent decline as an individual ages, dropping to approximately 80 ng/mL by age 60