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Description

Small GTPases

Extended bioavailability compared to native IGF-1 due to reduced binding protein interaction [2]

Animal studies have shown some teratogenic potentialis, so its not recommended during the first trimester of pregnancy

10.1007/s12325-022-02053-0 3 BattelinoT.DanneT.BergenstalR

UW228 shows partial sensitivity to SMO inhibitors and transient suppression of GLI1, with resistance mechanisms involving SUFU downregulation or GLI2 amplification