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However, there are multiple pathways that result in upregulation of COX-2 in brain neurons, including increased N-methyl-D-Aspartate (NMDA) receptor-dependent activity (230), cerebral ischemia, seizures, and diseases such as AD or PD (231)

A 2018 randomized controlled trial published in the European Journal of Clinical Nutrition tested this exact regimen in 48 participants consuming five standard drinks over four hours