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The Acarbose Cardiovascular Evaluation (ACE) trial, which enrolled 7,500 Chinese subjects (of which 6,522 completed the trial) with coronary heart disease and impaired glucose tolerance, found acarbose treatment for four months reduced the incidence of diabetes and promoted regression to normoglycemia (Gerstein 2020)

On the other hand, the oral, once-daily, centrally acting selective Y5-receptor antagonist velneperit, previously known as S-2367, induced a mean placebo-adjusted weight loss of 5.0% from initial weight (p 5% of initial body weight with a calorie restriction diet were allocated to receive either liraglutide or placebo, respectively, with mean weight loss -6.2% and -0.2%, respectively (120).Recently, Saxenda (liraglutide 3.0mg) has asked for a label update based on the results of the LEADER trial, which studied the effects of the lower dose version of liraglutide (1.8 mg) used to treat diabetes

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