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Chronic hyperglycemia promotes the formation of vascular plaques, resulting in narrowed vessel lumens, reduced blood flow, platelet aggregation, thrombosis, and eventually vascular occlusion or stroke [250]

Donnelly S, Haslett C, Reid P, Grant I, Wallace W, Metz C, Bruce L, Bucala R

For this reason, inflammation leads to insulin resistance and -cell dysfunction, which further aggravates hyperglycemia, the latter help perpetuate this deregulation

Mesotherapy is a minimally invasive treatment where a customized solution is injected into the middle layer of the skin (mesoderm) to target specific skin concerns

Nitration of glutamate transporters can inhibit their function, increasing the likelihood of excitotoxicity (Chen et al., 2010)