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Targeted therapy against ROS A synthetic antioxidant regimen has been established with four main approaches: lipid-lowering, blood pressure-lowering, thiol supplementation, and enzyme replacement Statins block the mevalonate pathway by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, reduce Rac1 membrane translocation, thereby lowering ROS derived from NOX, while stabilizing eNOS mRNA, increasing NO bioavailability, and inhibiting various adhesion molecules, achieving a dual suppression of oxidative stress and inflammation [486]

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The ultimate goals of preoperative medical assessment are to reduce the patients surgical and anesthetic perioperative morbidity or mortality, and to return him to desirable functioning as quickly as possible. A Zambouri [15] Laboratory tests are tailored to the patients age, medical history, and the complexity of the surgery

It also helps prevent the oxidation of LDL cholesterol, reducing the risk of plaque buildup in arteries and supporting vascular elasticitykey factors in maintaining cardiovascular function as we age