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Male C57BL/6J mice were injected with AAV8-TBG-GFP or AAV8-TBG-AGXT (2x10 11 viral genomes per mouse) and placed on the MASH diet for 24 weeks prior to end point analyses

Kanemura T, Tamaoki J, Horii S, Sakai N, Kobayashi K, Isono K, Takeuchi S, Takizawa T

A reduced redox state is essential for CSC self-renewal and, therefore, CCA CSCs were shown to rely on powerful antioxidant networks to detoxify mitochondrial reactive oxygen species and maintain stemness in oxidative CSCs

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