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Additionally, in line with the fact that HSP90 is highly activated in cancer cells, CHAMPs preferentially accumulate in tumors relative to levels in normal tissues, resulting in an improved therapeutic index compared with that of small molecule inhibitors

In particular, L-carnitine reduces the expression of glial fibrillary acidic protein, inducible nitric oxide synthase, ubiquitin and caspase 3 typical markers of cell stress

Using inmmunofluorescence, we found an increased expression of SAA1, SAA2 and SOX9 in hepatocytes, an overexpression of TREM2 and MMP19 in macrophages and an overexpression of ACKR1 and PLVAP in endothelial cells in the liver biopsies of patients with AH as compared to controls

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Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure