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GLS encodes kidney-type glutaminase (KGA) and its C-terminal truncated splice variant glutaminase C (GAC), the predominant form of GLS expressed in many cancers, while GLS2 is expressed as only one active isozyme, liver-type glutaminase (LGA)

Takeishi T, Hirano K, Kobayashi T, Hasegawa G, Hatakeyama K, Naito M

[47] conjugated MTX with a supramolecular self-assembling hydrogel composed of D-amino acids with a sequence of GDFDFDY, which was 2 -naphthoacetic (Nap) acid-glycine (G) -phenylalanine (F)-phenylalanine (F)-tyrosine (Y) (termed NapGFFY)

Key points Sickle cell disease is associated with semen parameter abnormalities in the majority of patients

Confirmation of a direct role for GSTP1 in chemotherapy response is important, not only in the prediction of response to platinum-based chemotherapy, but as a candidate response biomarker for new generation chemotherapy drugs, designed to exploit increased GSTP1 expression in tumours relative to surrounding normal tissues