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doi: 10.1038/s41586-020-2911-7 105 WangHZhangXZhangYShiTZhangYSongXet al

For measurement, organelle isolation often exaggerates apparent ROS production by disrupting matrix buffering and catalase activity, so in situ readouts with genetically encoded, peroxisome-targeted reporters (e.g., HyPer or roGFP-Orp1 fused to a PTS1/SKL signal) are preferred to capture authentic, compartment-confined dynamics (Fransen and Lismont 2024), Fig

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One way in which it might improve weight loss is through inhibition of pancreatic alpha amylase enzymes, changes in intestinal alpha glucosidase and alterations in fatty acid synthesis

Consistent with the OCR results, SDHB and Rieske expression levels were reduced in HMOX2 KO and DKO cells (Fig