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Secondary endpoints were defined as pharmacodynamics and pharmacokinetic parameters including maximum serum concentration, time to maximum concentration, half-life, plasma clearance, and volume of distribution, as well as exploratory parameters including bodyweight, glycemic control, and overall hormone profile

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Ultrasound of tendons and entheses can show thickening and power Doppler activity confirming active inflammation

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SFN protects against diabetic cardiomyopathy through increased NRF2 expression and correction of oxidative stress-induced modulation of the LKB1/AMPK pathway (259)