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Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci Transl Med

185 In an uncontrolled trial that included 52 men with infertility deemed not surgically treatable, 50 mg of saffron three times weekly for three months led to improvements in sperm motility and morphology, but not sperm counts

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PCC 6803 and Aquifex aeolicus having very low sequence similarity (~30%) to plant TyrAs ( clade III , Figure 2, Figure S1)