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Tendon and ligamentous injuries are common, as is bursitis, although inflammation is not usually a causative factor in the chronic symptoms these patients experience

Affecting redox-signaling via activation of Nrf2 and PPAR and inhibition of NF-B with additional synthesis of antioxidant enzymes (SOD, GSH-Px, GR, GST, CAT, etc.) and small antioxidant molecules (GSH)

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The research by Nilaksh Gupta and colleagues found that iodomethylcholine (IMC) can inhibit the production of microbial TMA in hosts and reduce plasma TMAO levels, demonstrating over 10,000-fold greater potency (sub-nanomolar IC50) compared to previously reported microbial choline TMA lyase inhibitors (Gupta et al., 2020)

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