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Targeting gut-liver axis for the treatment of nonalcoholic steatohepatitis: Translational and clinical evidence

By maintaining a strong presence in the intestinal lumen, charcoal acts as a sink for toxins excreted in the bile

286 Besides, -catenin responsive transcription (CRT) is another crucial therapeutic target in combating various cancers and CRT-inhibitory drugs (iCRT3, iCRT5, iCRT14) are specifically cytotoxic to human colon cancer cells and enhance the infiltration of T and NK cells in syngeneic mouse models of CRC by blocking -catenin/TCF interaction

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This dramatically reduces stomach capacity, lowers levels of ghrelin (the hunger hormone), and increases GLP-1 and PYY, contributing to reduced appetite and improved satiety