napqi and glutathione Alcohol paracetamol are both processed through the liver. Paracetamol can form a toxic metabolite called NAPQI, which the body usually neutralises safely. But factors like heavy alcohol use, repeated dosing, fasting 5️⃣ Antidote: NAC (N-acetylcysteine) NAC

5 Antidote: NAC (N acetylcysteine) NAC replenishes glutathione, restoring the ability to detoxify NAPQI. It's lifesaving if given early. Example: Hospitals use NAC as the standard treatment for APAP overdose. File:Acetaminophen metabolism.jpg Wikimedia Commons Acetaminophen metabolism and NAPQI mediated mitochondrial effects Download Scientific Diagram Biopharmaceutics and Drug Disposition Pharmacology Journal Wiley Online Library Acetaminophen (PARACETAMOL) INTOXICATION May Hospital, Shendam

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