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At the molecular level, our study identifies mTORC1 as an upstream regulator of ISR signaling in PBAT-MPs-induced microglial lipotoxicity along the gutbrain axis

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In the peptide hormone GPCRs, such as NTSR1, ET B R, and AT 2 receptor, the polar amino acids in the ligand binding pockets are important for recognition of the peptide cores of the endogenous ligands

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