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Upon further evaluation, the smaller brains of these littermates were likely due to an increase in caspase-3 activity by 53%, which was associated with a 46% increase in reactive oxidative species (ROS) levels

Analysis of obesity-related factors and their association with aromatase expression in canine malignant mammary tumours

Tong, X

Wang et al., 2006

In addition, the major mechanisms proposed to date are based on experimental models and few clinical studies, which have small sample sizes and uncontrolled designs