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The moderately elevated levels of 4-HNE ( 45 M) [161]

Here, this review summarized several validated and promising drug targets, exploring their structure and structure-based drug/inhibitor designs

And GAS could block the mitogen-activated protein kinases (MAPK) signal pathway, and suppress the inflammatory mediators such as cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB) and nuclear factor kappa-B (NF-B) phosphorylation, in PTZ-treated epileptic mice [35, 36]

Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, et al

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