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4) Integrate multi-disciplinary approaches for clinical translation: Combine artificial intelligence (AI)-driven drug discovery (e.g., machine learning models to predict ferroptosis modulator efficacy using multi-omics data) with network pharmacology to identify synergistic drug combinations (e.g., ferroptosis inhibitors + anti-fibrotic agents)

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Where human data exist, they are limited and methodologically weak, often lacking proper controls or large sample sizes

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Proof is primarily preclinical, and clinical translation necessitates careful scrutiny