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It occurs in the presence of poor aqueous tear flow, excessive tear evaporation, or a combination of these events, due to changes in tear composition and production [11]

78, 79 As NR4 subfamily nuclear receptors (e.g., Nur77, NURR1) are ubiquitous heterodimerization partners of RXR in forming heterodimers, 80 current study also revealed that when the cancer cells are incubated with HX600, a selective RXR agonist for Nur77-RXR and NURR1-RXR, the expression of CPTIA is induced through Nur77 or NURR1-mediated mechanism in the teratocarcinoma cells or heptoma carcinoma HepG2 cells 81 (Figure 3)

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Rofecoxib decreases renal injury in obese Zucker rats

However, the difference was not statistically significant