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are co-inventors on patents for the use of hookworm proteins as subunit vaccines against human hookworm disease

DC, dendritic cell

Animal cells also respond against oxidative stress by enhancing their PPP-directed NADPH production

Superoxide dismutase (SOD) Superoxide dismutases (SODs) are a group of key enzymes functioning as the first line of antioxidant defense by virtue of the ability to convert highly reactive superoxide radicals (dismutation) into hydrogen peroxide and molecular oxygen [54]

study ( In addition, CSD, a hallmark of migraine pathogenesis, can cause oxidative stress ( On a molecular basis, the TRPA1 (Transient receptor potential ankyrin subtype 1) ion channels in nociceptors allow the release of calcitonin gene-related peptide (CGRP) from dural afferents upon activation, mediating neurogenic inflammation, and migraine behavioral picture in animal models ( Neuroinflammation Neurogenic inflammation describes the phenomenon of arteriolar vasodilation, plasma protein extravasation, and degranulation of mast cells, caused by the release of potent vasoactive neuropeptides (mainly CGRP, substance P, and neurokinin A) from activated peripheral nociceptive nerve terminals