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doi: 10.1007/s40620-020-00789-y 21 FitzGeraldG

There were 23 clinical studies published between 2020 and 2025 that support collagen as a nutraceutical treatment that showed improvement in various skin attributes, but investigations are lacking on collagens effectiveness on scalp, hair, and nail health, which warrants further examination

It further dissects the role of lipid metabolism in reshaping the functions of T cells, B cells, macrophages, and dendritic cells, and delineates its organ-specific dysregulation in various ADs (e.g., synovium, skin, central nervous system, gut)