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The ferroptosis signalling pathway is comprehensive, and in addition to the classical disorders of iron metabolism, the glutathionecysteamineglutathione system and polyunsaturated fatty acid metabolism, an increasing number of signalling pathways, such as nicotinamide adenine dinucleotide phosphate/ferroptosis-inhibitory protein 1 and tetrahydrobiopterin/GPT cycloheximide 1/dihydrofolate reductase, have been identified 51

doi: 10.3322/caac.21834 2 SiegelRLMillerKDJemalA

Taken together, multimodal synergistic therapy on the basis of nanotechnology does provide revolutionized value and practical application in cancer therapy

Scientific References: Pompella, A., Visvikis, A., Paolicchi, A., De Tata, V., & Casini, A

Mouse studies reported changes in liver fat, inflammation and histology