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One of the major regulators for famine in bacteria is the RpoS sigma factor, which is involved in many other stress responses and is widely present throughout the prokaryotes

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doi: 10.1002/adma.202110364 345 LiangKLiZLuoYZhangQYinFXuLet al

They are seen in very high numbers in the brains of people with Alzheimers disease, meaning that milk thistle could potentially be used to help treat this difficult condition

Meurer MC, Mees M, Mariano LN, Boeing T, Somensi LB, Mariott M, Dos Santos AC, Longo B, Frana TC, Klein-Jnior LC, de Souza P