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In clinical trials, a single oral dose of macimorelin (0.5 mg/kg) was shown to be reliable and accurate for diagnosing adult GHD (49)

Chatterjee, S., Kundu, S., Bhattacharyya, A., Hartinger, C

This is an interesting point when you consider that in prostate cancer it has been shown that estrogen can substitute to upregulate IGF-1R when androgen levels are low (Turcu et al., 2017)