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Acknowledgements This work was financially supported by the National Key Research and Development Program of China (2024YFE0201200 [C.C.], 2023YFC3605600 [L.Y.]), the National Natural Science Foundations of China (52173133 [C.C.], 52161145402 [C.C.], 52373148 [C.C.], 82470962 [M.R.B.], U21A20368 [L.Y.]), Sichuan Science and Technology Program (2024NSFSC0672 [M.R.B.], 2023YFS0019 [L.Y.]), the State Key Laboratory of Polymer Materials Engineering (sklpme2021-4-02 [C.C.]), the 135 Project for Disciplines of Excellence, West China Hospital, Sichuan University (ZYJC21047 [C.C.]), Research Funding from West China School/Hospital of Stomatology Sichuan University (RCDWJS2023-16 [M.R.B.]), Research and Develop Program, West China Hospital of Stomatology Sichuan University (RD-02-202206 [M.R.B.]), and Med-X Innovation Program of Med-X Center for Materials, Sichuan University (MCMGD202301 [L.Y.])

Similar decrease in mRNA expression for MMP-2 ( P =0.001), SDF-1 ( P =0.001), TGF- ( P =0.001) and PARP ( P =0.001) was observed in NAC-treated rats