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Marei HE, Hasan A, Pozzoli G, Cenciarelli C

In this study, GLS inhibition reduced glutamine metabolism in prostate cancer cells, significantly decreasing the expression of stem cell markers (such as ALDH, OCT4, and Sox2), with the cells exhibiting reduced stemness characteristics

The ATP synthase beta subunit, a mitochondrial enzyme involved in redox regulation, associates with FUS, inducing the mitochondrial UPR in cellular and transgenic Drosophila models of ALS (Deng et al., 2018)