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HSC aging contributes to not only degeneration of the hematopoietic system, but also aging-associated inflammation and tissue functional decline, with organismal functional endpoints (treadmill endurance, inverted screen performance, spatial memory and glucose tolerance) as indicators of physiological relevance

doi:10.1038/s41467-018-04324-3

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All final percentile values were obtained in the last study 90 Clinically all children presented a good evolution, without intercurrences or intolerance to treatment