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[DOI] [PubMed] [Google Scholar] 235.Schuster G.U., Kenyon N.J., Stephensen C.B

The generation of ROS plays the role of indirect damage to tumor cells, and this is observed in a large portion of DNA damage caused by low linear energy transfer radiation, such as X- and gamma-rays 13,14 Thus, ROS is an important factor in controlling tumor cell radio-resistance 15 To counteract ROS production and survive radiation therapy, radio-resistant tumor cells maintain increased levels of reductants, such as GSH, which protect cells from oxidative damage through reaction with electrophiles or ROS 6,16,17

Elevated levels of AOPPs have been detected in the inflammatory diseases, diabetes, and the kidney failure [Cristani et al ., 2016

Curcumin-mediated resistance to lenvatinib via EGFR signaling pathway in hepatocellular carcinoma

Marcia et al., 2010a)