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doi:10.1016/S0893-133X(97)00181-4

Thus, we consider that together with other clinical variables and biomarkers, global MFIS and its domains constitute a diagnostic and prognostic aid in clinical practice for the design of personalized therapeutic strategies

Multicollinearity issues/too many overlapping covariates : In this work, we start with a large number of covariates (300+) and many covariates overlap i.e