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Furthermore, several approaches aim to target transcription and/or RNA export to counteract the effects of proinflammatory cytokines and inhibit viral protein synthesis: 1) Inhibition of Tat protein expression through didehydro-cortistatin A, 2) Inhibition of HIV integration and relocalization of the residual virus by Lens epithelium-derived growth factor p75, 3) Small interfering RNA (siRNA) silencing HIV gene transcription by recruiting Argonaute1, histone deacetylase 1, and histone methyltransferase, 4) Heat shock protein 90 inhibitors, Janus kinase (Jak)-STAT inhibitors, kinase inhibitors, and bromodomain protein 4 regulators, 5) CRISPR/Cas9-guided RNA [100, 186,187,188]