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Vidal-Alaball J, Butler CC, Cannings-John R, Goringe A, Hood K, McCaddon A, McDowell I, Papaioannou A

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The middle section highlights future precision targeting strategies, such as phage therapy for the precise clearance of pathogens like Klebsiella, engineered bacteria for the synthetic delivery of therapeutic molecules (e.g., IL-10), and microbial enzyme inhibitors targeting pathways like CutC/D to reduce harmful metabolites such as TMA/TMAO

Ferroptosis is regulated mainly by the GSH/GPX4 pathway 23

A redox shift is a change in the bioenergetic supply of electrons, leading to changes in the intracellular ratio of NAD + /NADH as redox currency, oxidized glutathione over GSH (GSSG/GSH) as redox buffer, and plasma cystine/cysteine (cySS/cys) as systemic buffer