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It is predicted that by 2050, the incidence rate of eye diseases such as myopia, diabetes retinopathy, macular degeneration and glaucoma will increase significantly ( Although some drugs and supplements have been used to treat blue light damage, their efficacy and safety still need further validation

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Many of these are involved in amino acid metabolism, nucleotide metabolism, and energy-related pathways, further supporting the notion of a time-dependent global metabolic downshift in control neurospheres