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Another detailed aspect of combination therapy involves the use of TGF- inhibitors alongside agents targeting other key signaling pathways implicated in fibrosis, such as the Wnt/-catenin or PI3K/Akt pathways (128)

Nat Chem Biol 6:801806

Expression of Fas and FasL depends on the stage of erythropoiesis, which allows regulating expansion of cells via inducing apoptosis of Fas-expressing immature erythroblasts by FasL-expressing mature erythroblasts [98]

TB-500 is a synthetic fragment used in research to study pathways related to Thymosin Beta-4

5l), and restored the expression of the DEX-mediated downexpression of GPX4 , SCL7A11 , PTGS2 , HSPB1 , FTH1 and TFR1 at mRNA level (Fig