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Notably, several aging-related signaling pathways are interconnected with the molecular clockwork

10.1016/s0021-9258(19)50300-3 119 LiY.MoucheS.SajicT.Veyrat-DurebexC.SupaleR.PierrozD.et al (2012)

this upregulation was caused by hypomethylation of its upstream promoter, which enhanced c-Jun binding

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