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DIABETES NEW WORLD 19 (20), 1819

Moreover, the accumulation of acetyl coenzyme A (acetyl-CoA) derived from BCAAs and BCKAs suppresses beigeing of WAT by acetylation of PR domain-containing protein 16 (PRDM16), whereas depletion of BCAA/BCKA-derived acetyl-CoA prompts WAT beigeing [60]

This was best summed up in a BMJ editorial last year, which noted that diagnosing B12 deficiency can be "challenging" because no "single specific measurement exists to reliably diagnose or refute the presence of B12 deficiency"