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Autoradiography and histopathology confirmed the PET imaging results

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2277-C ALPHA-1 ANTITRYPSIN/PROTEINASE 3 IMBALANCE EXERTS PROTEOLYTIC REGULATION ON INTERLEUKIN-32 GAMMA TO PROMOTE NONALCOHOLIC STEATOHEPATITIS JeongSu Park 1 , Jin Lee 2 , Feng Wang 1 , Hwan Ma 1 , Yong-Sun Lee 3 , SangKyu Lee 4 , Yoon Mee Yang 5 , Hwan-Soo Yoo 1 , Sang-Bae Han 1 , Bumseok Kim 6 , Jin Tae Hong 1 and Yoon-Seok Roh 1 , (1)Chungbuk National University, (2)University of California, San Diego, (3)National Institute of Food and Drug Safety Evaluation, South Korea, (4)Kyungpook National University, (5)Kangwon National University, (6)Biosafety Research Institute and College of Veterinary Medicine, Jeonbuk National University, Iksan 54596, Korea

As such, our work suggests a novel mechanism, regulated by C32E8.9 , is required for the beneficial longevity effects of mitochondrial translation inhibition, without altering UPR mt

however, compounded drugs themselves are not FDA-approved for safety or effectiveness