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Class I ferroptosis stimulants are compounds targeting system Xc (e.g., erastin [43], sorafenib [7], sulfasalazine [44], and glutamate [43, 45]), while inhibitors directly targeting GPx4 (e.g., RAS selective lethality protein 3 [RSL3], ML-162) are considered as Class II ferroptosis inducers [3, 46, 47]