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While NAD+ can be beneficial, another IV nutrient often overlooked is Glutathione and in many cases, it may be the better option

doi: 10.1128/mBio.00264-13 35 De BockM.Van HaverV.VandenbrouckeR

However, this is considered an underestimation as it will be unlikely to be detected in smaller clinical trials, and a more recent study in 2010 found that NSAIDs including ibuprofen (odds ratio of 2.24, 95% confidence interval (CI) = 1.992.52) increased the risk of hospitalization due to acute hepatitis (odds ratio 2.13, 95% CI = 22.18) 35

It's one of the greatest risk factors

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