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Three publicly available databases of biotinidase variants are accessible online: the Leiden Open Variation Database ( ClinVar ( and Biotinidase Deficiency and BTD , hosted by ARUP Laboratories ( Over 200 biotinidase variants are consolidated in the ARUP database, with more than 150 categorized as pathogenic

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A thinner needle (higher gauge) causes less discomfort but draws medication more slowly, which is why many patients use a wider drawing needle and switch to a thinner needle before injecting