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It does not cause clinically significant changes in blood pressure or prolong the QT interval, meaning it lacks a hypertension warning and can be safely used in patients with pre-existing hypertension (Staskin et al 2024)

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Peripheral neuropathy is the most common and represents the main cause of altered gait, neuropathic pain, foot ulceration, and amputation [58]

During the second week, thickening of the renal corpuscles, increased vascular wall thickness, and a reticulated collagen staining pattern in the medulla were noted